Metabolic Screening in Drug Development: In-Vivo to In-Silico
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چکیده
Submit Manuscript | http://medcraveonline.com Abbreviations: ADME: Absorption, Distribution, Metabolism and Excretion; NDA: New Drug Application; FDA: Food and Drug Administration; CYP: Cytochrome P; UGT: Uridine DiphosphoGlucuronosyl Transferase; NAT: N-Acetyl Transferase; GST: Glutathione S-Transferase; ST: Sulfo Transferase; QSAR: Quantitative Structure–Activity Relationships; PCA: Principal Components Analysis; CoMFA: Comparative Molecular Field Analysis; BBB: Blood–Brain Barrier; COMPACT: ComputerOptimised Molecular Parametric Analysis of Chemical Toxicity
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